Histone Modifications: Epigenetic Mediators of Environmental Exposure Memory
نویسندگان
چکیده
منابع مشابه
Evaluating the Role of Epigenetic Histone Modifications in the Metabolic Memory of Type 1 Diabetes
We assessed whether epigenetic histone posttranslational modifications are associated with the prolonged beneficial effects (metabolic memory) of intensive versus conventional therapy during the Diabetes Control and Complications Trial (DCCT) on the progression of microvascular outcomes in the long-term Epidemiology of Diabetes Interventions and Complications (EDIC) study. We performed chromati...
متن کاملEpigenetic Activation of SOX11 in Lymphoid Neoplasms by Histone Modifications
Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in stem cells, normal hematopoietic cells and different lymphoid neoplasms. We observed that SOX11 expression is associated with unmethylated DNA and pre...
متن کاملThe importance of epigenetic modifications in cancer progression
Epigenetics are dynamic and inherited changes in the genome that occur independently of DNA sequencing. This phenomenon requires coherent interaction with various enzymes and other molecular components. Abnormal epigenetic changes can lead to the onset of improper gene expression and the promotion of tumorigenesis. Because epigenetic changes are prone to external and reversible factors, they ar...
متن کاملTranscriptional memory emerges from cooperative histone modifications
1 Interdisciplinary Centre for Bioinformatics of Leipzig University, D-04107 Leipzig, Härtelstr. 16-18, Germany 2 Leipzig Interdisciplinary Research Cluster of Genetic Factors, Clinical Phenotypes and Environment (LIFE); Universität Leipzig, D-04103 Leipzig, Philipp-Rosenthalstr. 27, Germany 3 Computational EvoDevo Group, Institute of Computer Science, University of Leipzig, D-04107 Leipzig, Hä...
متن کاملP-98: Effect of Mouse Embryo Vitrification on Histone Modifications
Background: Vitrification has been usually used as an assisted reproductive technology in animals and humans. This method needs high concentrations of cryoprotectants that can be toxic with high cooling degrees. Then, vitrification could be change histone modifications such as methylation and acetylation can performance as regulatory controls of gene transcription. So, the purpose of the presen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Epigenetics Insights
سال: 2018
ISSN: 2516-8657,2516-8657
DOI: 10.1177/2516865718803641